N.N.Semenov Institute of Chemical Physics, Russian Academy of Science, Kosigin str. 4, Moscow 117977, Russia. E-mail: poltorakov@mtu-net.ru

Abstract

A modifed one site model of the bioreceptor have been used to estimate quantitatively the phenomenon of the full agonism. Thresh-old phenomenon, spare receptors and linear dependence of the biological effect on concentration of complex agonist-receptor has been determinate by the general correlation equations. The equations of one site model provides a good fit to the experimental curves "dose-response" for the full agonists and allows to calculate the value of spare receptors. The model includes occupancy Clark(s theory and law "all or nothing". The interaction of acetylcholine and alkyltrimethylammonium salt muscarinic acetylholine receptors is analysed as an example of use of this equation.